Mushroom Polysaccharides: Chemistry and Antiobesity, Antidiabetes, Anticancer, and Antibiotic Properties in Cells, Rodents, and Humans

Cancer prevention / treatments, Diabetes Prevention / Treatment, Immune System Support /

Mendel FriedmanCharles Brennan, Academic Editor Abstract More than 2000 species of edible and/or medicinal mushrooms have been identified to date, many of which are widely consumed, stimulating much research on their health-promoting properties. These properties are associated with bioactive compounds produced by the mushrooms, including polysaccharides. Although β-glucans (homopolysaccharides) are believed to be the major bioactive […]

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The Effects of Major Mushroom Bioactive Compounds on Mechanisms That Control Blood Glucose Level

Diabetes Prevention / Treatment /

Jelena Aramabašić Jovanović,* Mirjana Mihailović, Aleksandra Uskoković, Nevena Grdović, Svetlana Dinić, and Melita Vidaković Abstract Diabetes mellitus is a life-threatening multifactorial metabolic disorder characterized by high level of glucose in the blood. Diabetes and its chronic complications have a significant impact on human life, health systems, and countries’ economies. Currently, there are many commercial hypoglycemic drugs that are effective in

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Mycomedicine: A Unique Class of Natural Products with Potent Anti-tumour Bioactivities

Cancer prevention / treatments /

Rongchen Dai,1,† Mengfan Liu,1,† Wan Najbah Nik Nabil,1,2 Zhichao Xi,1,* and Hongxi Xu3,* Abstract   Mycomedicine is a unique class of natural medicine that has been widely used in Asian countries for thousands of years. Modern mycomedicine consists of fruiting bodies, spores, or other tissues of medicinal fungi, as well as bioactive components extracted from them, including polysaccharides and, triterpenoids,

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Immunomodulatory Effects of Edible and Medicinal Mushrooms and Their Bioactive Immunoregulatory Products

Immune System Support /

Shuang Zhao,1 Qi Gao,1 Chengbo Rong,1 Shouxian Wang,1 Zhekun Zhao,1,2 Yu Liu,1 and Jianping Xu3,* Abstract   Mushrooms have been valued as food and health supplements by humans for centuries. They are rich in dietary fiber, essential amino acids, minerals, and many bioactive compounds, especially those related to human immune system functions. Mushrooms contain diverse immunoregulatory compounds such as terpenes and terpenoids,

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Prevention of Early Alzheimer’s Disease by Erinacine A-Enriched Hericium erinaceus Mycelia Pilot Double-Blind Placebo-Controlled Study

Alzheimers Prevention / Treatment /

I-Chen Li,1 Han-Hsin Chang,2 Chuan-Han Lin,3 Wan-Ping Chen,1 Tsung-Han Lu,3 Li-Ya Lee,1 Yu-Wen Chen,1 Yen-Po Chen,1 Chin-Chu Chen,1,4,5,6,* and David Pei-Cheng Lin3,7,* Abstract Objective To investigate the efficacy and safety of three H. erinaceus mycelia (EAHE) capsules (350 mg/capsule; containing 5 mg/g erinacine A active ingredient) per day for the treatment of patients with mild Alzheimer’s Disease (AD). Methods This study comprised a 3-week no-drug screening period,

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Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells

Alzheimers Prevention / Treatment /

Koichiro Mori 1, Yutaro Obara, Mitsuru Hirota, Yoshihito Azumi, Satomi Kinugasa, Satoshi Inatomi, Norimichi Nakahata Abstract Neurotrophic factors are essential to maintain and organize neurons functionally; thereby neurotrophic factor-like substances or their inducers are expected to be applied to the treatment of neurodegenerative diseases such as Alzheimer’s disease. In the present study, we firstly examined the effects of ethanol extracts of four

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Improvement of cognitive functions by oral intake of Hericium erinaceus

Alzheimers Prevention / Treatment /

Yuusuke Saitsu 1, Akemi Nishide 2, Kenji Kikushima 3, Kuniyoshi Shimizu 4, Koichiro Ohnuki 1 Abstract Hericium erinaceus has been recognized as medical mushroom since ancient time, but its scientific evidence for human health has been still uncertain. In this study, we tested a randomized, double-blind, placebo-controlled parallel-group comparative study to evaluate the improvement of the cognitive functions by taking supplements containing fruiting body

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Key Mechanisms and Potential Implications of Hericium erinaceus in NLRP3 Inflammasome Activation by Reactive Oxygen Species during Alzheimer’s Disease

Alzheimers Prevention / Treatment /

by  Marika Cordaro1,†, Angela Trovato Salinaro 2,†,Rosalba Siracusa3,†,Ramona D’Amico 3,Daniela Impellizzeri3,Maria Scuto2,Maria Laura Ontario2,Salvatore Cuzzocrea3,Rosanna Di Paola3,*, Roberta Fusco  3,‡ andVittorio Calabrese2,‡ Abstract Alzheimer’s disease (AD) is the principal cause of dementia, and its incidence increases with age. Altered antioxidant systems and inflammation have an important role in the etiology of neurodegenerative disorders. In this study, we evaluated

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Hericium erinaceus: an edible mushroom with medicinal values

Alzheimers Prevention / Treatment, Immune System Support /

Md Asaduzzaman Khan 1, Mousumi Tania, Rui Liu, Mohammad Mijanur Rahman   Abstract Mushrooms are considered as nutritionally functional foods and source of physiologically beneficial medicines. Hericium erinaceus, also known as Lion’s Mane Mushroom or Hedgehog Mushroom, is an edible fungus, which has a long history of usage in traditional Chinese medicine. This mushroom is rich in some physiologically

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Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial

Alzheimers Prevention / Treatment /

Koichiro Mori 1, Satoshi Inatomi, Kenzi Ouchi, Yoshihito Azumi, Takashi Tuchida Abstract A double-blind, parallel-group, placebo-controlled trial was performed on 50- to 80-year-old Japanese men and women diagnosed with mild cognitive impairment in order to examine the efficacy of oral administration of Yamabushitake (Hericium erinaceus), an edible mushroom, for improving cognitive impairment, using a cognitive function scale based on the

Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial Read More »

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