Hui-Chuan Kuo, Data curation, Formal analysis, Resources, Validation, Writing – original draft,# 1 Sih-Yu Tong, Data curation, Formal analysis, Methodology, Writing – original draft,# 2 Ming-Wei Chao, Data curation, Formal analysis, Methodology, Resources, Writing – original draft,# 3 and Chia-Yi Tseng, Conceptualization, Formal analysis, Investigation, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing 2  Yasmina Abd‐Elhakim, Editor Abstract Lingzhi has long been regarded as having life-prolonging effects. Research in recent years has also reported that Lingzhi...

I-Chen Li,1 Han-Hsin Chang,2 Chuan-Han Lin,3 Wan-Ping Chen,1 Tsung-Han Lu,3 Li-Ya Lee,1 Yu-Wen Chen,1 Yen-Po Chen,1 Chin-Chu Chen,1,4,5,6,* and David Pei-Cheng Lin3,7,* Abstract Objective To investigate the efficacy and safety of three H. erinaceus mycelia (EAHE) capsules (350 mg/capsule; containing 5 mg/g erinacine A active ingredient) per day for the treatment of patients with mild Alzheimer’s Disease (AD). Methods This study comprised...

Koichiro Mori 1, Yutaro Obara, Mitsuru Hirota, Yoshihito Azumi, Satomi Kinugasa, Satoshi Inatomi, Norimichi Nakahata Abstract Neurotrophic factors are essential to maintain and organize neurons functionally; thereby neurotrophic factor-like substances or their inducers are expected to be applied to the treatment of neurodegenerative diseases such as Alzheimer’s disease. In the present study, we firstly examined the effects...

Yuusuke Saitsu 1, Akemi Nishide 2, Kenji Kikushima 3, Kuniyoshi Shimizu 4, Koichiro Ohnuki 1 Abstract Hericium erinaceus has been recognized as medical mushroom since ancient time, but its scientific evidence for human health has been still uncertain. In this study, we tested a randomized, double-blind, placebo-controlled parallel-group comparative study to evaluate the improvement of the cognitive functions by...

by  Marika Cordaro1,†, Angela Trovato Salinaro 2,†,Rosalba Siracusa3,†,Ramona D’Amico 3,Daniela Impellizzeri3,Maria Scuto2,Maria Laura Ontario2,Salvatore Cuzzocrea3,Rosanna Di Paola3,*, Roberta Fusco  3,‡ andVittorio Calabrese2,‡ Abstract Alzheimer’s disease (AD) is the principal cause of dementia, and its incidence increases with age. Altered antioxidant systems and inflammation have an important role in the etiology of neurodegenerative disorders....

Md Asaduzzaman Khan 1, Mousumi Tania, Rui Liu, Mohammad Mijanur Rahman   Abstract Mushrooms are considered as nutritionally functional foods and source of physiologically beneficial medicines. Hericium erinaceus, also known as Lion’s Mane Mushroom or Hedgehog Mushroom, is an edible fungus, which has a long history of usage in traditional Chinese medicine. This mushroom...

Koichiro Mori 1, Satoshi Inatomi, Kenzi Ouchi, Yoshihito Azumi, Takashi Tuchida Abstract A double-blind, parallel-group, placebo-controlled trial was performed on 50- to 80-year-old Japanese men and women diagnosed with mild cognitive impairment in order to examine the efficacy of oral administration of Yamabushitake (Hericium erinaceus), an edible mushroom, for improving cognitive impairment, using a cognitive...